This gene encodes a serum protein found in association with the major histocompatibility complex mhc class i heavy chain on the surface of nearly all nucleated cells. The method name for the same would be automated chemiluminescent immunometric assay. The implication and significance of beta 2 microglobulin. Since beta2 microglobulin b2m is a surrogate marker for middle molecular weight uremic toxins and the major protein component in dialysisrelated amyloidosis, it has been frequently studied in dialysis patients. Antibeta2microglobulin antibody products biocompare.
The information on this page was automatically extracted from online scientific databases. When impaired, serum levels rise in inverse ratio to glomerular filtration rate. Visible signs of microbial growth, turbidity, precipitate, or change in color in the. Beta 2 microglobulin is not diagnostic of a given disease but is usually an indicator of disease severity, e. Beta 2 microglobulin is a better predictor of treatment free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate. Beta2 microglobulin is synthesized in all nucleated cells and forms the light chain subunit of the major histocompatibility complex class i antigen. M is a small globular peptide with a molecular weight of 11800 da. Beta2 microglobulin b2m is a protein that is found on the surface of nucleated cells contain a nucleus and functions as part of the human immune system. Class i antigens are mostly expressed on lymphoid cells and expressed less on the lungs, kidney and liver and are sparsely expressed on skeletal muscle and the brain. The reference range of beta 2 microglobulin in urine samples is 00.
Notebeta2 microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. It is recommended that each laboratory establish its own normal and pathological ranges of urine levels. Serum work area assay overview cobas c 111 analyzer cobas. Avoid highly lipemic samples, which may produce excessively high. Certain characteristics of b2m make it suitable for detecting tumor cells, especially in blood and kidney cells. Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, nonhodgkins lymphoma, and multiple myeloma or kidney disease. Beta 2 microglobulin, urine is essentially a test which is performed on ones urine. In humans, this protein is encoded by the gene b2m. Yes, there are some scary conditions as well but beta2 microglobulin is not used for diagnostic purposes. Beta 2 microglobulin serum test test results, normal.
Oakland woods baptist church gavepodtrick letteratura del novecento patrice strike with tronikshow specials editions jesse the great podcast overly animated star wars rebels podcasts road rage podcast. Please help improve this article by adding citations to reliable sources. Despite its potential role as a convenient and noninvasive prognostic indicator in malignant lymphomas. The problem with cancer is that the body does not recognize these malignant cells as being foreign. Serum levels are therefore an index of glomerular function. Antibeta2 microglobulin antibodies are available from several suppliers. The b2m test can be used as a tumor marker for some people with blood cell cancers multiple myeloma, lymphoma to give information about their likely prognosis. During an immune response, mhc proteins, as well as beta2 microglobulin levels, increase. Validated in wb, ip, ihc, flow cyt and tested in mouse, rat, human.
Increased amounts of beta2 microglobulin are excreted in several renal disorders, e. Microglobulin definition of microglobulin by medical. Patients undergoing dialysis are unable to properly eliminate. Beta2microglobulin, serum test detail quest diagnostics. Rabbit recombinant monoclonal beta 2 microglobulin antibody epr21752214 bsa and azide free. Interpretation depends on the specific clinical indication and context. Beta2 microglobulin kidney disease lab tests online. Recombinant antibeta 2 microglobulin antibody ep2978y. The beta2 microglobulin elisa test is an enzyme immunoassay eia for the measurement of beta2 microglobulin in serum as an aid in the diagnosis of active rheumatoid arthritis and kidney disease. So this test works as a tumor marker for some hematologic malignancies. Guy sherwood the purpose of the bodys immune system is not only to recognize foreign antigens but also to be able to determine between self and not self. Definition beta 2 microglobulin is a protein found on the surface of many cells. Destination b2 grammar and vocabulary with answer key.
It is present in most body fluids and its level rises with conditions that increase cell production andor destruction, or that activate the immune system. Beta 2 microglobulin beta 2m is a low molecular weight protein of importance in the evaluation of the reabsorptive capacity of the proximal kidney tubule. Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds. Beta2 microglobulin is a cell membrane protein, exists in a protein complex termed mhc1 hla in humans. Recombinant antibeta 2 microglobulin antibody epr21752. Pdf comportamento della beta2microglobulina in alcune. Specimen collection and preparation a fasting serum specimen, free from hemolysis, is the recommended specimen. Beta 2 microglobulin an overview sciencedirect topics. B2 microglobulin test, beta 2 microglobulin elisa kit. This protein is routinely shed by cells into the blood and is present in most body fluids, with highest levels in the blood, generally lower levels in spinal fluid, and trace levels in urine. This article needs additional citations for verification.
Lee biosolutions is the leading producer and supplier of human urine beta2 microglobulin b2m for use in medical autoimmune research and manufacturing of clinical diagnostic assays. Beta2 microglobulin b2m is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by b lymphocytes and tumour cells. Beta2 microglobulin b2m is a protein shed by cells into the blood, including tumor cells. The protein may also be known as beta2 microglobulin, imd43, beta chain of mhc class i molecules, and beta2microglobin. Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, nonhodgkins lymphoma, and multiple myeloma or kidney disease purpose. Beta2 microglobulin is shed by the cells which becomes detectable in the bloodstream under normal conditions. It is not known, however, whether b2m has an impact in patients with chronic kidney disease ckd not yet on dialysis. The normal value of beta2 microglobulin is less than 2 mgl. Beta 2 microglobulin is a protein found on the surface of many cells. A local inflammatory reaction to beta2 microglobulin beta2 m amyloid deposits by monocytesmacrophages is a characteristic histologic feature of. Beta2 microglobulin b2m is a naturally occurring protein in the human body. A local inflammatory reaction to beta2 microglobulin beta2 m amyloid deposits by monocytesmacrophages is a characteristic histologic feature of dialysisrelated amyloidosis dra. The protein has a predominantly betapleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in.
Beta2 microglobulin, serum or plasma arup lab test. Beta2 microglobulin in the assessment of renal function in full term newborns following perinatal asphyxia. The capacity to assemble into amyloid fibrils is concentration dependent. Beta2 microglobulin, serum beta2 microglobulin normally passes through the glomerulus into the proximal tubule where much of it is reabsorbed. Circulating beta2 microglobulin and risk of cancer. However, serum b2m was not examined prospectively as a marker for cancer risk. It is one of two polypeptide chains that make up the structure of a major histocompatibility complex mhc class i molecule.
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